Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are useful markers of inflammation in polycystic ovary syndrome?

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic disorder characterized by hyperinsulinemia, abnormal lipid levels, altered hormonal milieu such as elevated androgen and chronic anovulation. PCOS one of the important reasons for infertility. most common cause irregular menstruation with diverse clinical manifestations affecting women reproductive age. Aims Objectives: The present study aimed to examine systemic inflammatory markers that can be detected in complete blood count, neutrophil–lymphocyte ratio (NLR) platelet–lymphocyte (PLR), patients compare them healthy women. Materials Methods: This case–control was conducted Department Obstetrics Gynecology, Akash Institute Medical Sciences Research Centre, Devanahalli, Bengaluru, Karnataka. After following inclusion exclusion criteria, total 160 subjects were included. Among them, 80 cases controls. A detailed gynecological history obtained from all subjects. Women presenting gynecology OPD group 15–45 years menstrual cycles included study. diagnosis done according Rotterdam requires presence at least two three symptoms: (1) oligomenorrhea/polymenorrhea; (2) biochemical hyperandrogenism (Ferriman–Gallwey scores ≥8) or hyperandrogenism; (3) detection polycystic ovaries an ultrasonographic examination (≥12 follicles, 2–10 mm size). Under aseptic conditions, venous samples collected assess hormones follicle-stimulating hormone (FSH), luteinizing (LH), markers, white cells, neutrophils (N), lymphocytes (L), platelets. NLR PLR calculated. Lipid profiles fasting state. Results: In study, BMI 24.5±4.1 kg/m2, cholesterol 160.1±24.2 mg/dL, triglyceride 99.1±28.1 LDLC 99.1±25.1 LH 8.4±3.8 mIU/mL, LH/FSH 1.2±0.91, 16.30±4.69, 5.73±1.91, 17.01±7.13 significantly increased HDLC 39.7±6.2 mg/dL FSH 6.1±1.1 mIU/mL decreased compared Conclusion: concludes age-matched individuals control group, suggesting low-grade inflammation early